Journal: The Journal of thoracic and cardiovascular surgery

Article Title: Recurrence after Neoadjuvant Chemoradiation and Surgery for Esophageal Cancer: Does the Pattern of Recurrence Differ for Complete Responders and Those with Partial or No response?

doi: 10.1016/j.jtcvs.2009.07.069

Figure Lengend Snippet: Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection.

Article Snippet: Thus, these data suggest that neoadjuvant chemoradiation delayed recurrence significantly and as well fewer patients failed (p=0.055). showing freedom from recurrence again underscores the fact that patients with CR have a significantly longer disease-free interval than patients with PR and NR (p=0.01). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1 caption a7 Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. table ft1 table-wrap mode="anchored" t5 caption a7 Complete Response Partial Response No Response P value Median IQR Median IQR Median IQR Within Radiation Field 5.8 4.7 - 9.3 7.1 3.5 - 18 8.5 7.5 - 62.3 0.604 Outside Radiation Field 27.3 12.3 - 31.1 5.7 3.9 - 15.8 9.1 6.9 - 14.5 0.008 Open in a separate window Median Disease-Free Survival of Patients with Recurrence (N=84) This impact of chemoradiation in preventing recurrence was of sufficient magnitude also to impact survival.

Techniques:

Journal: The Journal of thoracic and cardiovascular surgery

Article Title: Recurrence after Neoadjuvant Chemoradiation and Surgery for Esophageal Cancer: Does the Pattern of Recurrence Differ for Complete Responders and Those with Partial or No response?

doi: 10.1016/j.jtcvs.2009.07.069

Figure Lengend Snippet: Kaplan-Meier Estimates of Overall Survival of Esophageal Cancer Patients (n=267) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. The Kaplan-Meier estimates for overall survival indicate that as the extent of pathological response to neoadjuvant therapy increases, there is a significant increase in the overall survival of the patient. It is interesting to note, however, that in our observed cohort, the degree of pathological response to neoadjuvant therapy seemed not to affect patients with early mortality (<10 months) but rather those who survived more than one year.

Article Snippet: Thus, these data suggest that neoadjuvant chemoradiation delayed recurrence significantly and as well fewer patients failed (p=0.055). showing freedom from recurrence again underscores the fact that patients with CR have a significantly longer disease-free interval than patients with PR and NR (p=0.01). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1 caption a7 Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. table ft1 table-wrap mode="anchored" t5 caption a7 Complete Response Partial Response No Response P value Median IQR Median IQR Median IQR Within Radiation Field 5.8 4.7 - 9.3 7.1 3.5 - 18 8.5 7.5 - 62.3 0.604 Outside Radiation Field 27.3 12.3 - 31.1 5.7 3.9 - 15.8 9.1 6.9 - 14.5 0.008 Open in a separate window Median Disease-Free Survival of Patients with Recurrence (N=84) This impact of chemoradiation in preventing recurrence was of sufficient magnitude also to impact survival.

Techniques:

Journal: The Journal of thoracic and cardiovascular surgery

Article Title: Recurrence after Neoadjuvant Chemoradiation and Surgery for Esophageal Cancer: Does the Pattern of Recurrence Differ for Complete Responders and Those with Partial or No response?

doi: 10.1016/j.jtcvs.2009.07.069

Figure Lengend Snippet: Kaplan-Meier Estimates of Overall Survival of Esophageal Cancer Patients who had a complete pathological response to neoadjuvant therapy (n=82) at the Johns Hopkins Hospital, according to whether or not there was cancer recurrence following surgical resection.

Article Snippet: Thus, these data suggest that neoadjuvant chemoradiation delayed recurrence significantly and as well fewer patients failed (p=0.055). showing freedom from recurrence again underscores the fact that patients with CR have a significantly longer disease-free interval than patients with PR and NR (p=0.01). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1 caption a7 Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. table ft1 table-wrap mode="anchored" t5 caption a7 Complete Response Partial Response No Response P value Median IQR Median IQR Median IQR Within Radiation Field 5.8 4.7 - 9.3 7.1 3.5 - 18 8.5 7.5 - 62.3 0.604 Outside Radiation Field 27.3 12.3 - 31.1 5.7 3.9 - 15.8 9.1 6.9 - 14.5 0.008 Open in a separate window Median Disease-Free Survival of Patients with Recurrence (N=84) This impact of chemoradiation in preventing recurrence was of sufficient magnitude also to impact survival.

Techniques:

Journal: The Journal of thoracic and cardiovascular surgery

Article Title: Recurrence after Neoadjuvant Chemoradiation and Surgery for Esophageal Cancer: Does the Pattern of Recurrence Differ for Complete Responders and Those with Partial or No response?

doi: 10.1016/j.jtcvs.2009.07.069

Figure Lengend Snippet: Kaplan-Meier Estimates of Overall Survival of Esophageal Cancer Patients who had a partial pathological response to neoadjuvant therapy (n=108) at the Johns Hopkins Hospital, according to whether or not there was cancer recurrence following surgical resection.

Article Snippet: Thus, these data suggest that neoadjuvant chemoradiation delayed recurrence significantly and as well fewer patients failed (p=0.055). showing freedom from recurrence again underscores the fact that patients with CR have a significantly longer disease-free interval than patients with PR and NR (p=0.01). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1 caption a7 Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. table ft1 table-wrap mode="anchored" t5 caption a7 Complete Response Partial Response No Response P value Median IQR Median IQR Median IQR Within Radiation Field 5.8 4.7 - 9.3 7.1 3.5 - 18 8.5 7.5 - 62.3 0.604 Outside Radiation Field 27.3 12.3 - 31.1 5.7 3.9 - 15.8 9.1 6.9 - 14.5 0.008 Open in a separate window Median Disease-Free Survival of Patients with Recurrence (N=84) This impact of chemoradiation in preventing recurrence was of sufficient magnitude also to impact survival.

Techniques:

Journal: The Journal of thoracic and cardiovascular surgery

Article Title: Recurrence after Neoadjuvant Chemoradiation and Surgery for Esophageal Cancer: Does the Pattern of Recurrence Differ for Complete Responders and Those with Partial or No response?

doi: 10.1016/j.jtcvs.2009.07.069

Figure Lengend Snippet: Kaplan-Meier Estimates of Overall Survival of Esophageal Cancer Patients who had no pathological response to neoadjuvant therapy (n=71) at the Johns Hopkins Hospital, according to whether or not there was cancer recurrence following surgical resection.

Article Snippet: Thus, these data suggest that neoadjuvant chemoradiation delayed recurrence significantly and as well fewer patients failed (p=0.055). showing freedom from recurrence again underscores the fact that patients with CR have a significantly longer disease-free interval than patients with PR and NR (p=0.01). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1 caption a7 Kaplan-Meier Estimates of Recurrence-Free Survival of Esophageal Cancer Patients (n=261) at the Johns Hopkins Hospital, according to Pathological Response at Time of Surgical Resection. table ft1 table-wrap mode="anchored" t5 caption a7 Complete Response Partial Response No Response P value Median IQR Median IQR Median IQR Within Radiation Field 5.8 4.7 - 9.3 7.1 3.5 - 18 8.5 7.5 - 62.3 0.604 Outside Radiation Field 27.3 12.3 - 31.1 5.7 3.9 - 15.8 9.1 6.9 - 14.5 0.008 Open in a separate window Median Disease-Free Survival of Patients with Recurrence (N=84) This impact of chemoradiation in preventing recurrence was of sufficient magnitude also to impact survival.

Techniques: